Heavy hepatic impairment, infection induced by В and/or C hepatitis viruses (presence of infection Serological markers HBV and HCV), creatinine clearance less than 40 ml/min, concurrent administration of attenuated vaccines. Severe infections, active infections, including local. Pregnancy (no studies carried out in terms of safety and efficacy). Breast-feeding period. Childhood and age under 18 (no studies carried out in terms of safety and efficacy). Lactase deficiency, lactose intolerance, glucose-galactose malabsorption.